Recent trends in Cys- and Ser/Thr-based synthetic strategies for the elaboration of peptide constructs

Recent conceptual advances in the chemical synthesis of peptide constructs are described, encompassing native chemical ligation ( i.e. the chemoselective covalent condensation of unprotected peptide segments) and O- , S -acyl isopeptide strategies ( i.e. internal O , S -to- N acyl transfer within peptides). Recent conceptual advances in the chemical synthesis of peptide constructs are described, encompassing native chemical ligation ( i.e. the chemoselective covalent condensation of unprotected peptide segments) and O- , S -acyl isopeptide strategies ( i.e. internal O , S -to- N acyl transfer within peptides).