Catalytic asymmetric allylic alkylation employing heteroatom nucleophiles: a powerful method for C-X bond formation

Metal catalyzed asymmetric allylic alkylation (AAA) reactions have been an extensively studied and fruitful area of research in organic chemistry. The use of heteroatom-centered nucleophiles in this reaction is a powerful method for asymmetric C-X (X = heteroatom) bond formation. This perspective summarizes developments and applications of metal catalyzed AAA reactions employing heteroatom nucleophiles. The introduction of a diverse range of heteroatom nucleophiles by metal catalyzed allylic alkylations effects highly efficient regio- and enantioselective introduction of C-X bonds.