Molecularly imprinted nanotubes for enantioselective drug delivery and controlled release

Molecularly imprinted nanotubes for enantioselective drug delivery and controlled release are fabricated by the combination of template synthesis and ATRP grafting. The release of R -propranolol from the imprinted nanotubes in rats is restricted while the release of pharmacologically active S -enantiomer is greatly promoted. Molecularly imprinted nanotubes were prepared by the combination of template synthesis and ATRP grafting, and used in enantioselective drug delivery and controlled release. Pharmacokinetic studies revealed that the release of R -propranolol from the nanotubes in rats was restricted while the release of S -enantiomer was greatly promoted.