A two-photon fluorescent probe for near-membrane calcium ions in live cells and tissues

A two-photon fluorescent probe for near-membrane calcium ions in live cells and tissues

A two-photon fluorescent probe (ACaL) is reported that can be excited by 780 nm fs pulses, shows high photostability and negligible toxicity, and can visualize near-membrane Ca2+ in live cells and deep inside live tissues by two-photon microscopy.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2009-01 (36), p.5365
Hauptverfasser: Mohan, Palathurai Subramaniam, Lim, Chang Su, Tian, Yu Shun, Roh, Won Young, Lee, Jun Han, Cho, Bong Rae
Format: Artikel
Sprache:eng
Schlagworte:
2-Naphthylamine - analogs & derivatives
2-Naphthylamine - analysis
2-Naphthylamine - chemistry
Animals
Calcium - analysis
Calcium - chemistry
Calcium - metabolism
Calcium Signaling - drug effects
Cell Line, Tumor
Cell Membrane - metabolism
Cell Survival
Chelating Agents - chemistry
Chelating Agents - metabolism
Dentate Gyrus - metabolism
Egtazic Acid - analogs & derivatives
Egtazic Acid - chemistry
Egtazic Acid - pharmacology
Fluorescent Dyes - chemistry
Fluorescent Dyes - metabolism
Hippocampus - metabolism
Ions - analysis
Ions - chemistry
Laurates - chemistry
Liposomes - chemistry
Microscopy, Fluorescence
Molecular Structure
Osteoblasts - drug effects
Osteoblasts - metabolism
Parathyroid Hormone - pharmacology
Rats
Spectrometry, Fluorescence
Thapsigargin - pharmacology
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Beschreibung
Zusammenfassung:A two-photon fluorescent probe (ACaL) is reported that can be excited by 780 nm fs pulses, shows high photostability and negligible toxicity, and can visualize near-membrane Ca2+ in live cells and deep inside live tissues by two-photon microscopy.
ISSN:1359-7345
1364-548X
DOI:10.1039/b911337a