Highly efficient synthesis of aldenamines from carboxamides by iridium-catalyzed silane-reduction/dehydration under mild conditions

Highly efficient synthesis of aldenamines from carboxamides by iridium-catalyzed silane-reduction/dehydration under mild conditions

The combination of IrCl(CO)(PPh3)2 with 1,1,3,3-tetramethyldisiloxane or poly(methylhydrosiloxane) (PMHS) is found to be an efficient catalyst system for the preparation of aldenamines from carboxamides; in particular, facile removal of silicone and iridium residues from the product can be achieved...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2009-01 (12), p.1574
Hauptverfasser: Motoyama, Yukihiro, Aoki, Masaharu, Takaoka, Naoki, Aoto, Ryuta, Nagashima, Hideo
Format: Artikel
Sprache:eng
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Zusammenfassung:The combination of IrCl(CO)(PPh3)2 with 1,1,3,3-tetramethyldisiloxane or poly(methylhydrosiloxane) (PMHS) is found to be an efficient catalyst system for the preparation of aldenamines from carboxamides; in particular, facile removal of silicone and iridium residues from the product can be achieved by the use of PMHS.
ISSN:1359-7345
1364-548X
DOI:10.1039/b821317h