Synthesis, structure and biological activity of nitroxide malonate methanofullerenes

Two nitroxide methanofullerenes was synthesized for the first time, and their structures and biological activities studied. It was shown by X-ray single crystal analysis that the methanofullerene with two nitroxide groups forms a 1 : 2 inclusion complex with chloroform and has a nearly tetrahedral (...

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Veröffentlicht in:	Organic & biomolecular chemistry 2007-01, Vol.5 (6), p.976
Hauptverfasser:	Gubskaya, Valentina P, Berezhnaya, Lucia Sh, Gubaidullin, Aidar T, Faingold, Irina I, Kotelnikova, Raisa A, Konovalova, Nina P, Morozov, Vladimir I, Litvinov, Igor A, Nuretdinov, Ildus A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatography, High Pressure Liquid Crystallography, X-Ray Cyclophosphamide - therapeutic use Electron Spin Resonance Spectroscopy Fullerenes - chemistry Fullerenes - pharmacology Fullerenes - therapeutic use Leukemia - drug therapy Male Mice Models, Molecular Xenograft Model Antitumor Assays
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Zusammenfassung:	Two nitroxide methanofullerenes was synthesized for the first time, and their structures and biological activities studied. It was shown by X-ray single crystal analysis that the methanofullerene with two nitroxide groups forms a 1 : 2 inclusion complex with chloroform and has a nearly tetrahedral (diamond-like) arrangement of fullerene-fullerene interactions in the crystal. For the first time, it has been found that malonate nitroxide methanofullerene in combination with the known anticancer drug cyclophosphamide (CPA) shows high antitumor activity against leukemia P-388.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/b617892h