Biological activity of lyophilized chitosan scaffolds with inclusion of chitosan and zinc oxide nanoparticles

Biological activity of lyophilized chitosan scaffolds with inclusion of chitosan and zinc oxide nanoparticles

The constant demand for biocompatible and non-invasive materials for regenerative medicine in accidents and various diseases has driven the development of innovative biomaterials that promote biomedical applications. In this context, using sol-gel and ionotropic gelation methods, zinc oxide nanopart...

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Veröffentlicht in:RSC advances 2024-04, Vol.14 (19), p.13565-13582
Hauptverfasser: Viloria Angarita, Jorge Eliecer, Insuasty, Daniel, Rodríguez, Juan David, Castro, Jorge Iván, Valencia-Llano, Carlos Humberto, Zapata, Paula A, Delgado-Ospina, Johannes, Navia-Porras, Diana Paola, Albis, Alberto, Grande-Tovar, Carlos David
Format: Artikel
Sprache:eng
Schlagworte:
Biocompatibility
Biological activity
Biomedical materials
Chemistry
Chitosan
Degradation
F 2 region
Hydroxyapatite
Nanoparticles
Regenerative medicine
Scaffolds
Sol-gel processes
Tissue engineering
Zinc oxide
Zinc oxides
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Zusammenfassung:The constant demand for biocompatible and non-invasive materials for regenerative medicine in accidents and various diseases has driven the development of innovative biomaterials that promote biomedical applications. In this context, using sol-gel and ionotropic gelation methods, zinc oxide nanoparticles (NPs-ZnO) and chitosan nanoparticles (NPs-CS) were synthesized with sizes of 20.0 nm and 11.98 nm, respectively. These nanoparticles were incorporated into chitosan scaffolds through the freeze-drying method, generating a porous morphology with small (
ISSN:2046-2069
2046-2069
DOI:10.1039/d4ra00371c