Facile Ru-catalysed synthesis of quinazolin-4(3 H )-ones by tandem cyclization of 2-nitrobenzonitrile and alcohol derivatives under air

Facile Ru-catalysed synthesis of quinazolin-4(3 H )-ones by tandem cyclization of 2-nitrobenzonitrile and alcohol derivatives under air

We have developed an efficient approach for the first Ru-catalysed synthesis of 2-arylquinazolin-4(3 )-ones from 2-nitrobenzonitriles and alcohols. This method features a broad substrate scope, high yields, and functional group tolerance and does not require any oxidant or reductant, allowing for si...

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Veröffentlicht in:Organic & biomolecular chemistry 2025-01, Vol.23 (3), p.603-607
Hauptverfasser: Phuc, Ban Van, Nguyen, Tien Dat, Minh Tuan, Nguyen T, Dao, Phuong Anh, Thao Vy, Phan T, Nguyen, Hien, Nguyen, Ngoc Tuan, Ngo, Quoc Anh, Hung, Tran Quang, Dang, Tuan Thanh
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Chemical synthesis
Functional groups
Oxidants
Oxidizing agents
Reducing agents
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Zusammenfassung:We have developed an efficient approach for the first Ru-catalysed synthesis of 2-arylquinazolin-4(3 )-ones from 2-nitrobenzonitriles and alcohols. This method features a broad substrate scope, high yields, and functional group tolerance and does not require any oxidant or reductant, allowing for simple, practical and sustainable synthesis.
ISSN:1477-0520
1477-0539
1477-0539
DOI:10.1039/d4ob01786b