Synergetic antibacterial nanosheet based on Ti 3 C 2 T x photothermal therapy and cationic polymer to eradicate drug-resistant bacterial biofilms
Drug-resistant bacteria infection and biofilm formation on the wound still pose a tremendous challenge in post-antibiotic era. It has been proposed that multimode synergetic antibacterial strategies may be employed to eradicate drug-resistant bacteria and biofilms effectively. In this study, we synt...
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| Veröffentlicht in: | Nanoscale 2024-12, Vol.16 (47), p.21856-21868 |
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| creator | Pang, Chuming Tan, Yingxin Ling, Jiahao Hong, Liangzhi |
| description | Drug-resistant bacteria infection and biofilm formation on the wound still pose a tremendous challenge in post-antibiotic era. It has been proposed that multimode synergetic antibacterial strategies may be employed to eradicate drug-resistant bacteria and biofilms effectively. In this study, we synthesized non-invasive antibacterial two-dimension (2D) composite nanosheet BPG using Ti
C
T
MXene and cationic borneol-guanidine based polymers (B-PGMA-Gu)
simple electrostatically co-assemble. BPG can target bacteria and efficiently eliminate Gram-positive bacteria
(
), Gram-negative bacteria
(
), and
(MRSA) under 808 nm radiation. By combining the photothermal properties of Ti
C
T
MXene and the excellent membrane penetration ability of B-PGMA-Gu, MRSA biofilms can be effectively removed at 100 μg mL
under laser irradiation, resulting in a bactericidal efficiency of 99.1%. This method offers a more effective and rapid non-antibiotic method for removing biofilms. |
| doi_str_mv | 10.1039/d4nr03888f |
| format | Article |
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C
T
MXene and cationic borneol-guanidine based polymers (B-PGMA-Gu)
simple electrostatically co-assemble. BPG can target bacteria and efficiently eliminate Gram-positive bacteria
(
), Gram-negative bacteria
(
), and
(MRSA) under 808 nm radiation. By combining the photothermal properties of Ti
C
T
MXene and the excellent membrane penetration ability of B-PGMA-Gu, MRSA biofilms can be effectively removed at 100 μg mL
under laser irradiation, resulting in a bactericidal efficiency of 99.1%. This method offers a more effective and rapid non-antibiotic method for removing biofilms.</description><identifier>ISSN: 2040-3364</identifier><identifier>EISSN: 2040-3372</identifier><identifier>DOI: 10.1039/d4nr03888f</identifier><identifier>PMID: 39495172</identifier><language>eng</language><publisher>England</publisher><subject>Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Biofilms - drug effects ; Cations - chemistry ; Drug Resistance, Bacterial - drug effects ; Escherichia coli - drug effects ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Microbial Sensitivity Tests ; Nanostructures - chemistry ; Photothermal Therapy ; Polymers - chemistry ; Polymers - pharmacology ; Staphylococcus aureus - drug effects ; Titanium - chemistry ; Titanium - pharmacology</subject><ispartof>Nanoscale, 2024-12, Vol.16 (47), p.21856-21868</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c582-83a188193ee150f7eb0e69fe7149f609db6c323291b8ad827725357ac43189a23</cites><orcidid>0000-0002-2297-8013</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39495172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pang, Chuming</creatorcontrib><creatorcontrib>Tan, Yingxin</creatorcontrib><creatorcontrib>Ling, Jiahao</creatorcontrib><creatorcontrib>Hong, Liangzhi</creatorcontrib><title>Synergetic antibacterial nanosheet based on Ti 3 C 2 T x photothermal therapy and cationic polymer to eradicate drug-resistant bacterial biofilms</title><title>Nanoscale</title><addtitle>Nanoscale</addtitle><description>Drug-resistant bacteria infection and biofilm formation on the wound still pose a tremendous challenge in post-antibiotic era. It has been proposed that multimode synergetic antibacterial strategies may be employed to eradicate drug-resistant bacteria and biofilms effectively. In this study, we synthesized non-invasive antibacterial two-dimension (2D) composite nanosheet BPG using Ti
C
T
MXene and cationic borneol-guanidine based polymers (B-PGMA-Gu)
simple electrostatically co-assemble. BPG can target bacteria and efficiently eliminate Gram-positive bacteria
(
), Gram-negative bacteria
(
), and
(MRSA) under 808 nm radiation. By combining the photothermal properties of Ti
C
T
MXene and the excellent membrane penetration ability of B-PGMA-Gu, MRSA biofilms can be effectively removed at 100 μg mL
under laser irradiation, resulting in a bactericidal efficiency of 99.1%. This method offers a more effective and rapid non-antibiotic method for removing biofilms.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Biofilms - drug effects</subject><subject>Cations - chemistry</subject><subject>Drug Resistance, Bacterial - drug effects</subject><subject>Escherichia coli - drug effects</subject><subject>Methicillin-Resistant Staphylococcus aureus - drug effects</subject><subject>Microbial Sensitivity Tests</subject><subject>Nanostructures - chemistry</subject><subject>Photothermal Therapy</subject><subject>Polymers - chemistry</subject><subject>Polymers - pharmacology</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Titanium - chemistry</subject><subject>Titanium - pharmacology</subject><issn>2040-3364</issn><issn>2040-3372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkN9KwzAYxYMobk5vfADJtVBN8vVPcinTqTAUtPclbb9ukbUpSQb2MXxjO6fz6hw4P86BQ8glZzecgbqt484xkFI2R2QqWMwigEwcH3waT8iZ9x-MpQpSOCUTULFKeCam5Ot96NCtMJiK6i6YUlcBndEb2unO-jVioKX2WFPb0dxQoHMqaE4_ab-2wYY1unaEd6r7YayoaaWDsd3Y19vN0KKjwdIxrc0YIK3ddhU59MaHcY_-75XGNmbT-nNy0uiNx4tfnZF88ZDPn6Ll6-Pz_G4ZVYkUkQTNpeQKEHnCmgxLhqlqMOOxalKm6jKtQIBQvJS6liLLRAJJpqsYuFRawIxc72srZ7132BS9M612Q8FZsbu1uI9f3n5uXYzw1R7ut2WL9QH9-xG-AchIdJE</recordid><startdate>20241205</startdate><enddate>20241205</enddate><creator>Pang, Chuming</creator><creator>Tan, Yingxin</creator><creator>Ling, Jiahao</creator><creator>Hong, Liangzhi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-2297-8013</orcidid></search><sort><creationdate>20241205</creationdate><title>Synergetic antibacterial nanosheet based on Ti 3 C 2 T x photothermal therapy and cationic polymer to eradicate drug-resistant bacterial biofilms</title><author>Pang, Chuming ; Tan, Yingxin ; Ling, Jiahao ; Hong, Liangzhi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c582-83a188193ee150f7eb0e69fe7149f609db6c323291b8ad827725357ac43189a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Biofilms - drug effects</topic><topic>Cations - chemistry</topic><topic>Drug Resistance, Bacterial - drug effects</topic><topic>Escherichia coli - drug effects</topic><topic>Methicillin-Resistant Staphylococcus aureus - drug effects</topic><topic>Microbial Sensitivity Tests</topic><topic>Nanostructures - chemistry</topic><topic>Photothermal Therapy</topic><topic>Polymers - chemistry</topic><topic>Polymers - pharmacology</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Titanium - chemistry</topic><topic>Titanium - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pang, Chuming</creatorcontrib><creatorcontrib>Tan, Yingxin</creatorcontrib><creatorcontrib>Ling, Jiahao</creatorcontrib><creatorcontrib>Hong, Liangzhi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Nanoscale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pang, Chuming</au><au>Tan, Yingxin</au><au>Ling, Jiahao</au><au>Hong, Liangzhi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synergetic antibacterial nanosheet based on Ti 3 C 2 T x photothermal therapy and cationic polymer to eradicate drug-resistant bacterial biofilms</atitle><jtitle>Nanoscale</jtitle><addtitle>Nanoscale</addtitle><date>2024-12-05</date><risdate>2024</risdate><volume>16</volume><issue>47</issue><spage>21856</spage><epage>21868</epage><pages>21856-21868</pages><issn>2040-3364</issn><eissn>2040-3372</eissn><abstract>Drug-resistant bacteria infection and biofilm formation on the wound still pose a tremendous challenge in post-antibiotic era. It has been proposed that multimode synergetic antibacterial strategies may be employed to eradicate drug-resistant bacteria and biofilms effectively. In this study, we synthesized non-invasive antibacterial two-dimension (2D) composite nanosheet BPG using Ti
C
T
MXene and cationic borneol-guanidine based polymers (B-PGMA-Gu)
simple electrostatically co-assemble. BPG can target bacteria and efficiently eliminate Gram-positive bacteria
(
), Gram-negative bacteria
(
), and
(MRSA) under 808 nm radiation. By combining the photothermal properties of Ti
C
T
MXene and the excellent membrane penetration ability of B-PGMA-Gu, MRSA biofilms can be effectively removed at 100 μg mL
under laser irradiation, resulting in a bactericidal efficiency of 99.1%. This method offers a more effective and rapid non-antibiotic method for removing biofilms.</abstract><cop>England</cop><pmid>39495172</pmid><doi>10.1039/d4nr03888f</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-2297-8013</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2040-3364 |
| ispartof | Nanoscale, 2024-12, Vol.16 (47), p.21856-21868 |
| issn | 2040-3364 2040-3372 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_D4NR03888F |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Biofilms - drug effects Cations - chemistry Drug Resistance, Bacterial - drug effects Escherichia coli - drug effects Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Nanostructures - chemistry Photothermal Therapy Polymers - chemistry Polymers - pharmacology Staphylococcus aureus - drug effects Titanium - chemistry Titanium - pharmacology |
| title | Synergetic antibacterial nanosheet based on Ti 3 C 2 T x photothermal therapy and cationic polymer to eradicate drug-resistant bacterial biofilms |
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