Synergetic antibacterial nanosheet based on Ti 3 C 2 T x photothermal therapy and cationic polymer to eradicate drug-resistant bacterial biofilms

Drug-resistant bacteria infection and biofilm formation on the wound still pose a tremendous challenge in post-antibiotic era. It has been proposed that multimode synergetic antibacterial strategies may be employed to eradicate drug-resistant bacteria and biofilms effectively. In this study, we synthesized non-invasive antibacterial two-dimension (2D) composite nanosheet BPG using Ti C T MXene and cationic borneol-guanidine based polymers (B-PGMA-Gu) simple electrostatically co-assemble. BPG can target bacteria and efficiently eliminate Gram-positive bacteria ( ), Gram-negative bacteria ( ), and (MRSA) under 808 nm radiation. By combining the photothermal properties of Ti C T MXene and the excellent membrane penetration ability of B-PGMA-Gu, MRSA biofilms can be effectively removed at 100 μg mL under laser irradiation, resulting in a bactericidal efficiency of 99.1%. This method offers a more effective and rapid non-antibiotic method for removing biofilms.