Biological effects and mechanisms of dietary chalcones: latest research progress, future research strategies, and challenges

Dietary plants are an indispensable part of the human diet, and the various natural active compounds they contain, especially polyphenols, polysaccharides, and amino acids, have always been a hot topic of research among nutritionists. As precursors to polyphenolic substances in dietary plants, chalcones are not only widely distributed but also possess a variety of biological activities due to their unique structure. However, there has not yet been a comprehensive article summarizing the biological activities and mechanisms of dietary chalcones. This review began by discussing the dietary sources and bioavailability of chalcones, providing a comprehensive description of their biological activities and mechanisms of action in antioxidation, anti-inflammation, anti-tumor, and resistance to pathogenic microbes. Additionally, based on the latest research findings, some future research strategies and challenges for dietary chalcones have been proposed, including computer-aided design and molecular docking, targeted biosynthesis and derivative design, interactions between the gut microbiota and chalcones, as well as clinical research. It is expected that this review will contribute to supplementing the scientific understanding of dietary chalcones and promoting their practical application and the development of new food products. Chalcones are widely distributed in food and have multiple biological activities; there are limitations and drawbacks in the application of dietary chalcones in food; future research strategies and key issues for dietary chalcones.