Electrochemical hydrocarboxylation of enol derivatives with CO 2 : access to β-acetoxycarboxylic acids

Electrochemical hydrocarboxylation of enol derivatives with CO 2 : access to β-acetoxycarboxylic acids

Electrochemical hydrocarboxylation of enol acetates with CO is developed. The disclosed process provides β-acetoxycarboxylic acids in 25-66% yields, in contrast to the electrolysis of ketones, silyl enol ethers and vinyl tosylates with CO , which leads mainly to alcohols.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2024-07, Vol.60 (62), p.8099-8102
Hauptverfasser: Ustyuzhanin, Alexander O, Bityukov, Oleg V, Sokolovskiy, Pavel V, Merkulova, Valentina M, Ilovaisky, Alexey I, He, Liang-Nian, Vil', Vera A, Terent'ev, Alexander O
Format: Artikel
Sprache:eng
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Zusammenfassung:Electrochemical hydrocarboxylation of enol acetates with CO is developed. The disclosed process provides β-acetoxycarboxylic acids in 25-66% yields, in contrast to the electrolysis of ketones, silyl enol ethers and vinyl tosylates with CO , which leads mainly to alcohols.
ISSN:1359-7345
1364-548X
DOI:10.1039/d4cc02831g