Iodine-promoted synthesis of CF 3 -substituted dihydroimidazobenzimidazole and CF 3 -dihydroimidazoindole via C-N bond formation

Iodine-promoted synthesis of CF 3 -substituted dihydroimidazobenzimidazole and CF 3 -dihydroimidazoindole via C-N bond formation

The iodine-promoted cyclization of various -(2-CF -2-NHTs)ethylbenzimidazoles and -(2-CF -2-NHTs)ethylindoles proceeded smoothly and efficiently under mild basic conditions. This reaction did not require transition metals and afforded the corresponding CF -dihydroimidazobenzimidazoles and CF -dihydr...

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Veröffentlicht in:Organic & biomolecular chemistry 2023-08, Vol.21 (33), p.6762-6771
Hauptverfasser: Komatsu, Daiki, Yamada, Kasumi, Hanamoto, Takeshi
Format: Artikel
Sprache:eng
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Zusammenfassung:The iodine-promoted cyclization of various -(2-CF -2-NHTs)ethylbenzimidazoles and -(2-CF -2-NHTs)ethylindoles proceeded smoothly and efficiently under mild basic conditions. This reaction did not require transition metals and afforded the corresponding CF -dihydroimidazobenzimidazoles and CF -dihydroimidazoindoles in 85-93% and 42-82% yields, respectively.
ISSN:1477-0520
1477-0539
DOI:10.1039/D3OB01124K