A green, practical & scalable approach towards the synthesis of valuable α-keto amides using a metal-free catalyst under solvent-free conditions

α-Ketoamides are very important motifs as they are present in many natural products, drugs & biologically important molecules. We synthesized a very simple, cheap, eco-friendly & reusable glucose-based carbonaceous material (GCM), which showed high performance as a catalyst in the oxidative cross-dehydrogenative coupling (CDC) reaction of α-ketoaldehydes with amines for the synthesis of α-ketoamides. The GCM catalyst was also very efficient for one-pot two-step synthesis of α-ketoamides from α-ketoalcohols as well. The GCM catalyst was able to catalyze alcohol oxidation in α-ketoalcohols followed by CDC reaction with amines to form α-ketoalcohols. The reactions were found to proceed smoothly at a low temperature of 50 °C using a green & economical metal-free catalyst under base-free, ligand-free & solvent-free reaction conditions to get the corresponding α-ketoamides in good to excellent yields. The results demonstrated that the GCM catalyst showed acidic as well as superior oxidising catalytic activity due to the presence of a carboxylic acid (-COOH) and hydroxyl (-OH)-enriched carbonaceous framework, which enabled the synthesis of important α-ketoamide motifs. The applicability of the catalyst was also evaluated for the synthesis of an anti-HIV agent drug molecule. Greener, cheaper & eco-friendly GCM catalyst as well as catalytic process for synthesis of α-Keto Amides.