Visible light-induced C(sp)-S bond formation

The thiolation of C(sp 3 )-H with thioacids is for the first time reported through a new visible light-induced radical relay strategy. This strategy features metal-free and additive-free conditions, excellent atom economy, and high yields (up to 98%). The present methodology shows good functional group tolerance such as cyanos, halogens, or heterocycles and could be further applied to the one-pot preparation of ketones from thioacids by a tandem photocatalytic radical coupling reaction and the Liebeskind-Srogl cross-coupling reaction. The conversion of unactivated C(sp 3 )-H to C(sp 3 )-S bond was realized through a light-induced radical relay way involving successive SET and HAT process. Ketones could be prepared from thioacids by tandem photocatalytic radical coupling reaction.