Trinuclear rhenium()-based metallocages as anticancer agents towards human cervical cancer cells

The first examples of spherical-shaped trinuclear rhenium( i ) organometallic cages displaying cytotoxic, antimetastatic, antiproliferative and DNA-damaging behavior towards a human cervical (HeLa) cancer cell line are reported. The compact design of the metallocages facilitates their interactions with biosystems leading to comparable efficiency to that of the commonly used anticancer drug cisplatin. In vitro cytotoxicity studies of self-assembled compact trinuclear rhenium(I) based metallocages display anticancer, antimetastatic, antiproliferative and DNA damaging behavior towards human cervical cancer cells comparable to that of cisplatin.