Recent advances in Rh()-catalyzed enantioselective C-H functionalization

Chiral carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds are pervasive and very essential in natural products, bioactive molecules, and functional materials, and their catalytic construction has emerged as one of the hottest research fields in synthetic organic chemistry. The last decade has witnessed vigorous progress in Rh( i )-catalyzed asymmetric C-H functionalization as a complement to Rh( ii ) and Rh( iii ) catalysis. This review aims to provide the most comprehensive and up-to-date summary covering the recent advances in Rh( i )-catalyzed C-H activation for asymmetric functionalization. In addition to the development of diverse reactions, chiral ligand design and mechanistic investigation (inner-sphere mechanism, outer-sphere mechanism, and 1,4-Rh migration) will also be highlighted. This review aims to provide the most comprehensive and up-to-date summary of recent advances in Rh( i )-catalyzed enantioselective C−H functionalization highlighting diverse reaction development, chiral ligand design and mechanistic investigation.