Effective assessment of lanthanide ion delivery into live cells by paramagnetic NMR spectroscopy
We report an effective assessment of lanthanide ion (Ln 3+ ) delivery into live cells by paramagnetic NMR spectroscopy. Free Ln 3+ ions are toxic to live cells resulting in a gradual leakage of target proteins to the extracellular media. The citrate-Ln 3+ complex is an efficient and mild reagent ove...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2023-08, Vol.59 (7), p.1552-1555 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | We report an effective assessment of lanthanide ion (Ln
3+
) delivery into live cells by paramagnetic NMR spectroscopy. Free Ln
3+
ions are toxic to live cells resulting in a gradual leakage of target proteins to the extracellular media. The citrate-Ln
3+
complex is an efficient and mild reagent over the free Ln
3+
form for live cell delivery.
The citrate-Ln
3+
complex is an efficient and mild reagent over free Ln
3+
for live cell delivery assessed by paramagnetic NMR spectroscopy. |
|---|---|
| ISSN: | 1359-7345 1364-548X |
| DOI: | 10.1039/d3cc03135g |