Palladium-catalyzed distal selective C-H chalcogenation of biphenyl amines

A palladium-catalyzed distal C(sp 2 )-H chalcogenation of biphenyl amines is described. This protocol demonstrates scalability, excellent chemo- and regio-selectivity, and broad functional group tolerance, providing efficient access to valuable aryl chalcogenides. Notably, the chalcogenated biphenyl amines could be further transformed to 8-membered N, Se(S)-heterocycles through copper-catalyzed intramolecular C-N cyclization. Herein, we describe a palladium-catalyzed distal C-H chalcogenation of biphenyl amines, affording a series of valuable aryl chalcogenides, which could be further transformed to 8-membered N, Se(S)-heterocycles through intramolecular C-N cyclization.