A general scheme for generating NMR supersequences combining high- and low-sensitivity experiments

NOAH supersequences are a way of collecting multiple 2D NMR experiments in a single measurement. So far, this approach has been limited to experiments with comparable sensitivity. Here, we propose a scheme which overcomes this limitation, combining experiments with very different sensitivities such as 1,1-ADEQUATE, 15 N HMBC, and 13 C HSQC. The vertical interleaving of NOAH supersequences combines modules with very differing sensitivities.