Mechanically active small intestinal submucosa hydrogel for accelerating chronic wound healing

Mechanically active small intestinal submucosa hydrogel for accelerating chronic wound healing

The treatment of chronic wounds is still a challenge worldwide. Here, inspired by mechanically induced embryonic wound healing, we design a mechanically active small intestinal submucosa based hydrogel (SIS-PNIPAm). The mechanical activity, biocompatibility, and bioactivity (angiogenesis and immunor...

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Veröffentlicht in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2022-08, Vol.1 (33), p.6279-6286
Hauptverfasser: Chen, Xiao-Ya, Wang, Yi, Ma, Shi-Qing, Huang, Yi-Qian, Jing, Wei, Wei, Peng-Fei, Yu, Xue-Qiao, Zhao, Bo
Format: Artikel
Sprache:eng
Schlagworte:
Angiogenesis
Biocompatibility
Biological activity
Diabetes mellitus
Embryos
Hydrogels
Immunoregulation
Intestine
Wound healing
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Zusammenfassung:The treatment of chronic wounds is still a challenge worldwide. Here, inspired by mechanically induced embryonic wound healing, we design a mechanically active small intestinal submucosa based hydrogel (SIS-PNIPAm). The mechanical activity, biocompatibility, and bioactivity (angiogenesis and immunoregulation) of the SIS-PNIPAm hydrogel enable the fast healing of diabetic rat full-thickness wounds. The treatment of chronic wounds is still a challenge worldwide.
ISSN:2050-750X
2050-7518
DOI:10.1039/d2tb01355j