Direct fluoroalkylthiolation of indoles with iodofluoroethane enabled by Na 2 S 2 O 4
In this paper, we report an efficient approach for the direct fluoroalkylthiolation of indoles with iodofluoroethane in the presence of Na S O . In this work, we employed readily available iodofluoroethane and Na S O as fluoroalkylthiolation reagents, featuring mild conditions and a wide range of in...
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| Veröffentlicht in: | RSC advances 2022-12, Vol.13 (1), p.730-733 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | In this paper, we report an efficient approach for the direct fluoroalkylthiolation of indoles with iodofluoroethane in the presence of Na
S
O
. In this work, we employed readily available iodofluoroethane and Na
S
O
as fluoroalkylthiolation reagents, featuring mild conditions and a wide range of indole substrates. In addition, fluoroalkylthiolated 2,3'-biindole derivatives can also be prepared by this method. |
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| ISSN: | 2046-2069 2046-2069 |
| DOI: | 10.1039/d2ra07430c |