Silver-catalysed double decarboxylative addition-cyclisation-elimination cascade sequence for the synthesis of quinolin-2-ones

An atom-efficient silver-catalysed double carboxylative strategy for the one-step synthesis of quinolin-2-ones via an addition-cyclisation-elimination cascade sequence of oxamic acids to acrylic acids, mediated either thermally or photochemically, is reported. The reaction was applicable to the synthesis of a broad range of quinolin-2-ones and featured a double-disconnection approach that constructed the quinolin-2-one core via the formal and direct addition of a C(sp 2 )-H/C(sp 2 )-H olefin moiety to a phenylformamide precursor. Thermal and photochemical silver-catalysed cascade sequence for the synthesis of quinolin-2-ones is reported. The reaction features two radical decarboxylations and proceeds via the formal addition of an olefin moiety to a phenylformamide precursor.