Iron-catalysed reductive coupling for the synthesis of polyfluorinated compounds

Herein we reported the use of Earth-abundant iron as the catalytic metal in the presence of Mn to induce difluorobromoacetates to form carbon radicals, which reacted with trifluoromethyl olefins followed by -F elimination to generate the corresponding gem -difluoroolefins. The cross-electrophile coupling displayed excellent functional group tolerance and broad substrate scope under mild reductive conditions, affording a large number of polyfluorinated compounds, which could be further transformed to other valuable molecules. Iron-catalysed reductive cross-coupling of difluorobromo acetic acid derivatives with trifluoromethyl olefins to afford polyfluorinated molecules, containing a difluorenyl and difluoroalkyl group, with a broad substrate scope.