Organic photoredox catalyzed dealkylation/acylation of tertiary amines to access amides

A mild metal-free C-N bond activation strategy for the direct conversion of inert tertiary amines with acyl chlorides into tertiary amides via organic photoredox catalysis is presented. In this protocol, a novel organic photocatalyst (Cz-NI-Ph) that showed excellent catalytic performance during C-N bond cleavage is developed. Moreover, this reaction features green and mild conditions, broad substrate scope, and readily available raw materials. A novel C-N bond activation strategy was established by developing new organic photoredox catalyst (Cz-NI-Ph), which provides a concise approach for the synthesis of amides from tertiary amines.