Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2 H -pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones

Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2 H -pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones

A convenient preparative method is developed allowing for expeditious assembly of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2 -pyrrol-2-ones from routinely available inexpensive synthetic precursors. These compounds could not be prepared the previously known protocols, as 2-aminofuran derivatives...

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Veröffentlicht in:RSC advances 2021-04, Vol.11 (27), p.16236-16245
Hauptverfasser: Aksenov, Nicolai A, Aksenov, Dmitrii A, Kurenkov, Igor A, Aksenov, Alexander V, Skomorokhov, Anton A, Prityko, Lidiya A, Rubin, Michael
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Sprache:eng
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Zusammenfassung:A convenient preparative method is developed allowing for expeditious assembly of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2 -pyrrol-2-ones from routinely available inexpensive synthetic precursors. These compounds could not be prepared the previously known protocols, as 2-aminofuran derivatives were produced instead.
ISSN:2046-2069
2046-2069
DOI:10.1039/d1ra02279b