Near-infrared light-responsive photothermal α-Fe 2 O 3 @Au/PDA core/shell nanostructure with on-off controllable anti-bacterial effects

Antimicrobial materials are expected to be alternatives for antibiotics against multidrug-resistant bacteria. In this paper, non-spherical α-Fe O @Au/PDA core/shell nanoparticles with tunable shapes are synthesized by a one-step oxidation-redox polymerization method toward near infrared light-responsive antibacterial therapy. The thickness and composition of the Au/PDA hybrid shell can be controlled by varying the concentration of HAuCl and the dopamine precursor. Owing to the wonderful photothermal characteristics originating from the Au/PDA shell, the spindle α-Fe O @Au/PDA core shell nanoparticles exhibit excellent photothermal sterilization effects against both and at low concentrations. Meanwhile, the NIR photothermal induced bactericidal performance indicates that α-Fe O @Au/PDA hybrid particles with tunable non-spherical shapes possess unique controllable antibacterial effects. As a result, this finding provides a simple strategy for fabricating high performance photothermal antibacterial agents and the final products possess high potential in synergistic antimicrobial therapy.