Broadened bioactivity and enhanced durability of two structurally distinct metal-organic frameworks containing Zn 2+ ions and thiabendazole

Broadened bioactivity and enhanced durability of two structurally distinct metal-organic frameworks containing Zn 2+ ions and thiabendazole

Novel metal-organic frameworks (MOFs) based on thiabendazole (TBZ) were developed. The two structurally distinct TBZ-MOFs synthesized in this study exhibited enhanced durability and a broader biocidal spectrum than either individual bioactive species (i.e., Zn2+ and TBZ). The characteristics of each...

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Veröffentlicht in:Dalton transactions : an international journal of inorganic chemistry 2021-06, Vol.50 (21), p.7176-7180
Hauptverfasser: Kobayashi, Daiya, Hamakawa, Akira, Yamaguchi, Yuki, Takahashi, Toshiaki, Yanagita, Mitsuhiro, Arai, Shigebumi, Minoura, Mao
Format: Artikel
Sprache:eng
Schlagworte:
Ions - chemistry
Metal-Organic Frameworks - chemistry
Metal-Organic Frameworks - pharmacology
Microbial Sensitivity Tests
Molecular Structure
Solubility
Thiabendazole - chemistry
Thiabendazole - pharmacology
Zinc - chemistry
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Zusammenfassung:Novel metal-organic frameworks (MOFs) based on thiabendazole (TBZ) were developed. The two structurally distinct TBZ-MOFs synthesized in this study exhibited enhanced durability and a broader biocidal spectrum than either individual bioactive species (i.e., Zn2+ and TBZ). The characteristics of each TBZ-MOF are related to the coordination modes among the Zn2+ ions and ligand donors. The difference in water solubility between the two TBZ-MOFs due to the structural design allows for the controlled release of the desired bioactive component.
ISSN:1477-9226
1477-9234
DOI:10.1039/D1DT00733E