A {CdClO} cluster functionalized sandwich-type tungstoarsenate as a conformation modulator for misfolding Aβ peptides

A nanoscale polyoxometalate {[H 2 dap] 6 [Cd 4 Cl 2 (B-α-AsW 9 O 34 ) 2 ]} based on a tetra-Cd cluster sandwiched by trivacant Keggin-type tungstoarsenate was successfully designed and synthesized. It can modulate the β-sheet-rich fibrils of Aβ peptides efficiently and thus inhibits the production of reactive oxygen species originating from these Aβ aggregates. A nanoscale polyoxometalate {[H 2 dap] 6 [Cd 4 Cl 2 (B-α-AsW 9 O 34 ) 2 ]} based on tetra-Cd cluster sandwiched trivacant Keggin-type tungstoarsenate was successfully synthesized, which it can modulate the β-sheet-rich fibrils of Aβ peptide efficiently.