ZIF-8 with cationic defects toward efficient 125 I 2 uptake for in vitro radiotherapy of colon cancer

ZIF-8 with cationic defects toward efficient 125 I 2 uptake for in vitro radiotherapy of colon cancer

Introducing 2,3-dimethyl-1 -imidazol-3-ium iodide (Dmim) as a monodentate ligand during the preparation of ZIF-8 yields ZIF-8 + (50) and ZIF-8 + (38) with cationic 'missing linker' defects. ZIF-8 + (38) adsorbs I and the resulting radioactive host-guest complex exhibits cytotoxicity compar...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-06, Vol.58 (49), p.6942-6945
Hauptverfasser: Tian, Xin-Xin, Liu, Yi-Tong, Li, Yan, Qiu, Xin-Yu, Zhang, Wen-Hua, Young, David J, Chen, Qiu
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container_issue 49
container_start_page 6942
container_title Chemical communications (Cambridge, England)
container_volume 58
creator Tian, Xin-Xin
Liu, Yi-Tong
Li, Yan
Qiu, Xin-Yu
Zhang, Wen-Hua
Young, David J
Chen, Qiu
description Introducing 2,3-dimethyl-1 -imidazol-3-ium iodide (Dmim) as a monodentate ligand during the preparation of ZIF-8 yields ZIF-8 + (50) and ZIF-8 + (38) with cationic 'missing linker' defects. ZIF-8 + (38) adsorbs I and the resulting radioactive host-guest complex exhibits cytotoxicity comparable to that of Na I against colon cancer cell line CT26.
doi_str_mv 10.1039/D1CC07304D
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title ZIF-8 with cationic defects toward efficient 125 I 2 uptake for in vitro radiotherapy of colon cancer
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