ZIF-8 with cationic defects toward efficient 125 I 2 uptake for in vitro radiotherapy of colon cancer

ZIF-8 with cationic defects toward efficient 125 I 2 uptake for in vitro radiotherapy of colon cancer

Introducing 2,3-dimethyl-1 -imidazol-3-ium iodide (Dmim) as a monodentate ligand during the preparation of ZIF-8 yields ZIF-8 + (50) and ZIF-8 + (38) with cationic 'missing linker' defects. ZIF-8 + (38) adsorbs I and the resulting radioactive host-guest complex exhibits cytotoxicity compar...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-06, Vol.58 (49), p.6942-6945
Hauptverfasser: Tian, Xin-Xin, Liu, Yi-Tong, Li, Yan, Qiu, Xin-Yu, Zhang, Wen-Hua, Young, David J, Chen, Qiu
Format: Artikel
Sprache:eng
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Zusammenfassung:Introducing 2,3-dimethyl-1 -imidazol-3-ium iodide (Dmim) as a monodentate ligand during the preparation of ZIF-8 yields ZIF-8 + (50) and ZIF-8 + (38) with cationic 'missing linker' defects. ZIF-8 + (38) adsorbs I and the resulting radioactive host-guest complex exhibits cytotoxicity comparable to that of Na I against colon cancer cell line CT26.
ISSN:1359-7345
1364-548X
DOI:10.1039/D1CC07304D