Reversible regulation of metallo-base-pair interactions for DNA dehybridization by ultrasound

Mechanical force applied by ultrasound in solution leads to the dissociation of DNA metallo-base-pair interactions when these motifs are functionalized with oligodeoxynucleotide sequences of sufficient length. The annealing and force-induced denaturing process is followed by the attachment of distance-sensitive fluorescent probes and is found to be reversible. Ultrasound leads to the reversible dissociation of DNA metallo-base-pairs when these motifs are functionalized with oligodeoxynucleotide sequences of sufficient length.