BODIPY-vinyl dibromides as triplet sensitisers for photodynamic therapy and triplet-triplet annihilation upconversion

BODIPY-vinyl dibromides as triplet sensitisers for photodynamic therapy and triplet-triplet annihilation upconversion

We devised a new generation of halogen-based triplet sensitisers comprising geminal dibromides at the vinyl backbone of a BODIPY fluorophore. Incorporating geminal dibromides into the π-conjugation of BODIPY enhanced intersystem crossing due to the heavy atom effect, which in turn improved the exten...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2021-06, Vol.57 (49), p.639-642
Hauptverfasser: Dartar, Suay, Ucuncu, Muhammed, Karakus, Erman, Hou, Yuqi, Zhao, Jianzhang, Emrullahoglu, Mustafa
Format: Artikel
Sprache:eng
Schlagworte:
Conjugation
Dibromides
Photodynamic therapy
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Zusammenfassung:We devised a new generation of halogen-based triplet sensitisers comprising geminal dibromides at the vinyl backbone of a BODIPY fluorophore. Incorporating geminal dibromides into the π-conjugation of BODIPY enhanced intersystem crossing due to the heavy atom effect, which in turn improved the extent of excited triplet states. BODIPY-vinyl dibromides as triplet sensitisers with a fine balance between fluorescence emission and singlet oxygen generation. A promising tool for imaging-guided photodynamic therapy.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc01881g