Interrupted aza-Wittig reactions using iminophosphoranes to synthesize 11 C-carbonyls

Interrupted aza-Wittig reactions using iminophosphoranes to synthesize 11 C-carbonyls

A direct CO2-fixation methodology couples structurally diverse iminophosphoranes with various nucleophiles to synthesize ureas, carbamates, thiocarbamates, and amides, and is amenable for 11C radiolabeling. This methodology is practical, as demonstrated by the synthesis of >35 products and isolat...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2021-05, Vol.57 (43), p.5266-5269
Hauptverfasser: Ismailani, Uzair S, Munch, Maxime, Mair, Braeden A, Rotstein, Benjamin H
Format: Artikel
Sprache:eng
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Zusammenfassung:A direct CO2-fixation methodology couples structurally diverse iminophosphoranes with various nucleophiles to synthesize ureas, carbamates, thiocarbamates, and amides, and is amenable for 11C radiolabeling. This methodology is practical, as demonstrated by the synthesis of >35 products and isolation of the molecular imaging radiopharmaceuticals [11C]URB694 and [11C]glibenclamide.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc01016f