Planar chiral palladacycle precatalysts for asymmetric synthesis

Chiral non-racemic palladacycles were employed as precatalysts for Pd(0) mediated asymmetric synthesis. Addition of HPAr 2 /base to a ferrocenyloxazoline planar chiral palladacycle resulted in ligand synthesis and palladium capture to give a bidentate Phosferrox/Pd(0) complex. A series of these complexes were generated in situ and applied successfully as catalysts for asymmetric allylic alkylation. The first demonstration of a chiral palladacycle precatalyst in Pd(0) mediated asymmetric synthesis is achieved by a novel ligand synthesis/palladium capture procedure.