An organocatalytic C-C bond cleavage approach: a metal-free and peroxide-free facile method for the synthesis of amide derivatives
A facile organocatalytic approach has been devised towards the synthesis of amide derivatives using 1,3-dicarbonyls as easily available acyl-sources under peroxide-free reaction conditions. This transformation was accomplished by the cleavage of the C-C bond in the presence of TEMPO as an organocata...
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| Veröffentlicht in: | New journal of chemistry 2020-12, Vol.44 (48), p.294-2944 |
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| container_end_page | 2944 |
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| container_issue | 48 |
| container_start_page | 294 |
| container_title | New journal of chemistry |
| container_volume | 44 |
| creator | Vodnala, Nagaraju Gujjarappa, Raghuram Polina, Saibabu Satheesh, Vanaparthi Kaldhi, Dhananjaya Kabi, Arup K Malakar, Chandi C |
| description | A facile organocatalytic approach has been devised towards the synthesis of amide derivatives using 1,3-dicarbonyls as easily available acyl-sources under peroxide-free reaction conditions. This transformation was accomplished by the cleavage of the C-C bond in the presence of TEMPO as an organocatalyst and excludes the use of transition-metals and harsh reaction conditions. A broad range of substrates with diverse functional groups were well tolerated and delivered the products in high yields.
An organocatalyzed C-C bond cleavage approach has been envisioned towards the synthesis of amide derivatives from their corresponding amines and 1,3-dicarbonyls. |
| doi_str_mv | 10.1039/d0nj04158k |
| format | Article |
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An organocatalyzed C-C bond cleavage approach has been envisioned towards the synthesis of amide derivatives from their corresponding amines and 1,3-dicarbonyls.</description><subject>Cleavage</subject><subject>Covalent bonds</subject><subject>Derivatives</subject><subject>Functional groups</subject><subject>Substrates</subject><subject>Synthesis</subject><subject>Transition metals</subject><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpF0UtPwzAMAOAKgcQYXLgjReKGVIibNG25TePNBJfdKzePraNrStJN7MovJ1AEJ1vWJ1u2o-gU6CVQVlwp2q4ohzR_24tGwEQRF4mA_ZAD5zFNuTiMjrxfUQqQCRhFn5OWWLfA1krssdn1tSTTeEoq2yoiG41bXGiCXecsyuU1QbLWwcXG6VAOptPOftRKDxWDsm70t1laRYx1pF9q4ndtCL72xBqC66CJ0q7eYl9vtT-ODgw2Xp_8xnE0v7udTx_i2ev943QyiyXjWR8nAIVkCDxFToXIBUtyLqTKdcIVyyWoCmkFVBmd52CYSipB0yoDXsmMV2wcnQ9twyrvG-37cmU3rg0Ty4QHxRLBIaiLQUlnvXfalJ2r1-h2JdDy-8TlDX15-jnxc8BnA3Ze_rn_F7Av5tp5Ag</recordid><startdate>20201228</startdate><enddate>20201228</enddate><creator>Vodnala, Nagaraju</creator><creator>Gujjarappa, Raghuram</creator><creator>Polina, Saibabu</creator><creator>Satheesh, Vanaparthi</creator><creator>Kaldhi, Dhananjaya</creator><creator>Kabi, Arup K</creator><creator>Malakar, Chandi C</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>H9R</scope><scope>JG9</scope><scope>KA0</scope><orcidid>https://orcid.org/0000-0002-2586-3190</orcidid><orcidid>https://orcid.org/0000-0002-9478-017X</orcidid></search><sort><creationdate>20201228</creationdate><title>An organocatalytic C-C bond cleavage approach: a metal-free and peroxide-free facile method for the synthesis of amide derivatives</title><author>Vodnala, Nagaraju ; Gujjarappa, Raghuram ; Polina, Saibabu ; Satheesh, Vanaparthi ; Kaldhi, Dhananjaya ; Kabi, Arup K ; Malakar, Chandi C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-2119c3a145a40668632846cd8e24d38c1dba0b10dfe881f3d2b605b714bc74b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cleavage</topic><topic>Covalent bonds</topic><topic>Derivatives</topic><topic>Functional groups</topic><topic>Substrates</topic><topic>Synthesis</topic><topic>Transition metals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vodnala, Nagaraju</creatorcontrib><creatorcontrib>Gujjarappa, Raghuram</creatorcontrib><creatorcontrib>Polina, Saibabu</creatorcontrib><creatorcontrib>Satheesh, Vanaparthi</creatorcontrib><creatorcontrib>Kaldhi, Dhananjaya</creatorcontrib><creatorcontrib>Kabi, Arup K</creatorcontrib><creatorcontrib>Malakar, Chandi C</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Illustrata: Natural Sciences</collection><collection>Materials Research Database</collection><collection>ProQuest Illustrata: Technology Collection</collection><jtitle>New journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vodnala, Nagaraju</au><au>Gujjarappa, Raghuram</au><au>Polina, Saibabu</au><au>Satheesh, Vanaparthi</au><au>Kaldhi, Dhananjaya</au><au>Kabi, Arup K</au><au>Malakar, Chandi C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An organocatalytic C-C bond cleavage approach: a metal-free and peroxide-free facile method for the synthesis of amide derivatives</atitle><jtitle>New journal of chemistry</jtitle><date>2020-12-28</date><risdate>2020</risdate><volume>44</volume><issue>48</issue><spage>294</spage><epage>2944</epage><pages>294-2944</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>A facile organocatalytic approach has been devised towards the synthesis of amide derivatives using 1,3-dicarbonyls as easily available acyl-sources under peroxide-free reaction conditions. This transformation was accomplished by the cleavage of the C-C bond in the presence of TEMPO as an organocatalyst and excludes the use of transition-metals and harsh reaction conditions. A broad range of substrates with diverse functional groups were well tolerated and delivered the products in high yields.
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| fulltext | fulltext |
| identifier | ISSN: 1144-0546 |
| ispartof | New journal of chemistry, 2020-12, Vol.44 (48), p.294-2944 |
| issn | 1144-0546 1369-9261 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Cleavage Covalent bonds Derivatives Functional groups Substrates Synthesis Transition metals |
| title | An organocatalytic C-C bond cleavage approach: a metal-free and peroxide-free facile method for the synthesis of amide derivatives |
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