An organocatalytic C-C bond cleavage approach: a metal-free and peroxide-free facile method for the synthesis of amide derivatives

A facile organocatalytic approach has been devised towards the synthesis of amide derivatives using 1,3-dicarbonyls as easily available acyl-sources under peroxide-free reaction conditions. This transformation was accomplished by the cleavage of the C-C bond in the presence of TEMPO as an organocatalyst and excludes the use of transition-metals and harsh reaction conditions. A broad range of substrates with diverse functional groups were well tolerated and delivered the products in high yields. An organocatalyzed C-C bond cleavage approach has been envisioned towards the synthesis of amide derivatives from their corresponding amines and 1,3-dicarbonyls.