Three-component ruthenium-catalyzed remote C-H functionalization of 8-aminoquinoline amides

Multicomponent reactions can efficiently construct complex molecular structures from simple precursors. Herein, a novel ruthenium-catalyzed three-component highly selective remote C-H functionalization of 8-aminoquinoline amides has been described. The reaction tolerates a wide range of functional groups, producing arylation/difluoroalkylation products of olefins with potential biological activity and pharmaceutical value. Radical scavenging and radical clock experiments show that a free radical process is involved and a H/D exchange experiment suggests that the reaction might involve ortho -C-H activation of the aromatic ring. A possible mechanism is proposed. Multicomponent reactions can efficiently construct complex molecular structures from simple precursors.