Rhodium-catalysed diastereo- and enantio-selective cyclopropanation of α-boryl styrenes

Rhodium-catalysed diastereo- and enantio-selective cyclopropanation of α-boryl styrenes

A rhodium-catalyzed diastereo- and enantio-selective cyclopropanation of α-boryl styrenes with α-diazoarylacetates was established. Rh 2 ( S -PTTL) 4 (0.2 mol%) was found to be effective for the conversion, and 21 diastereopure cyclopropylboronates were prepared in high yields with excellent enantio...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-10, Vol.56 (82), p.12379-12382
Hauptverfasser: Sun, Xiao, Gu, Peiming, Qin, Jiao, Su, Yan
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Crystallography
Enantiomers
Rhodium
Styrenes
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Zusammenfassung:A rhodium-catalyzed diastereo- and enantio-selective cyclopropanation of α-boryl styrenes with α-diazoarylacetates was established. Rh 2 ( S -PTTL) 4 (0.2 mol%) was found to be effective for the conversion, and 21 diastereopure cyclopropylboronates were prepared in high yields with excellent enantioselectivity (ee up to 99%). A rhodium-catalyzed diastereo- and enantio-selective cyclopropanation of α-boryl styrenes with α-diazoarylacetates was established.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc02549f