Novel copper-based and pH-sensitive nanomedicine for enhanced chemodynamic therapy

We utilized albumin as a reducing agent to establish novel copper-based and pH-sensitive nanocarrier CuNPs with abundant Cu + , which can encapsulate histone deacetylase (HDAC) inhibitor vorinostat to form uniform and stable nanomedicine V-CuNPs for synergistic chromatin remodelling and chemodynamic therapy. We utilized albumin as reducing agent to establish a novel pH-sensitive nanocarrier with abundant Cu + , which can encapsulate HDAC inhibitor vorinostat to form uniform V-CuNPs for synergistic chromatin remodelling and chemodynamic therapy.