Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use

Paracetamol poisoning was first reported in 1966. The development of antidotes followed within 10 years, and by 1980 acetylcysteine (NAC) was acknowledged as the optimal therapy available. This article examines the history of the development of NAC and recent developments in its use. We offer sugges...

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Veröffentlicht in:Toxicology research (Cambridge) 2019-07, Vol.8 (4), p.489-498
Hauptverfasser: Bateman, D. Nicholas, Dear, James W
Format: Artikel
Sprache:eng
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Zusammenfassung:Paracetamol poisoning was first reported in 1966. The development of antidotes followed within 10 years, and by 1980 acetylcysteine (NAC) was acknowledged as the optimal therapy available. This article examines the history of the development of NAC and recent developments in its use. We offer suggestions for improvements in the way NAC may be administered and outline new developments that should have major impacts on the way we manage paracetamol poisoning in the near future. Matthew and Rumack (200 mg or UK 'Prescott' line) and the 150 mg Treatment line, both on log scales.
ISSN:2045-452X
2045-4538
DOI:10.1039/c9tx00002j