Adenosine triphosphate responsive metal-organic frameworks equipped with a DNA structure lock for construction of a ratiometric SERS biosensor

A novel ratiometric surface-enhanced Raman scattering (SERS) biosensor was constructed based on stimuli-responsive DNA functionalized metal organic frameworks (MOFs) for detection of adenosine triphosphate (ATP). As a result, the detection range of ATP was 1 nM to 200 nM with a detection limit of 0.4 nM. The ratiometric SERS biosensor strategy offers a lower detection limit and exhibits a more enhanced performance than the typical SERS detection based on single signal response, which may have potential for detection of other biomolecules or metal ions. DNA structure functionalized MOFs for construction of a ratiometric SERS biosensor to sensitively detect ATP.