A general diversity oriented synthesis of asymmetric double-decker shaped silsesquioxanes

A strategically novel synthesis of nano-sized, asymmetrically functionalized double-decker shaped silsesquioxanes (DDSQ) is reported. Selective protection with a boronic acid affords the crucial mono-protected intermediate en route to the asymmetric products. Generation of symmetric by-products is minimized by judicious choice of base, and high recovery of recyclable starting DDSQ tetraol is achieved. A strategically novel synthesis of nano-sized, asymmetrically functionalized double-decker shaped silsesquioxanes (DDSQ) is reported.