A mitochondria-nucleolus migration fluorescent probe for monitoring of mitochondrial membrane potential and identification of cell apoptosis

A mitochondria-nucleolus migration fluorescent probe for monitoring of mitochondrial membrane potential and identification of cell apoptosis

A dicationic probe ( Cz-Bz-1 ) was presented with excellent photostability and large Stokes shifts, which could migrate from mitochondria to the nucleolus and report mitochondrial membrane potential (MMP) changes. Moreover, Cz-Bz-1 was successfully applied to visualize the decrease of MMP induced by...

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Veröffentlicht in:Analytical methods 2019-12, Vol.11 (45), p.575-5754
Hauptverfasser: Li, Meng-Yang, Liu, Yan-Hong, Li, Kun, Zhang, Hong, Shi, Lei, Liu, Xin-Yao, Yu, Kang-Kang, Yu, Xiao-Qi
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Fluorescent indicators
Hydrogen peroxide
Membrane potential
Membranes
Mitochondria
Nucleoli
Platinum
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Zusammenfassung:A dicationic probe ( Cz-Bz-1 ) was presented with excellent photostability and large Stokes shifts, which could migrate from mitochondria to the nucleolus and report mitochondrial membrane potential (MMP) changes. Moreover, Cz-Bz-1 was successfully applied to visualize the decrease of MMP induced by H 2 O 2 and cis -platinum during cell apoptosis. A fluorescent probe with large Stokes shifts and excellent photostability was reported for monitoring mitochondria-nucleolus migration.
ISSN:1759-9660
1759-9679
DOI:10.1039/c9ay01836k