A photoredox catalyzed iminyl radical-triggered C-C bond cleavage/addition/Kornblum oxidation cascade of oxime esters and styrenes: synthesis of ketonitriles

A photoredox catalyzed iminyl radical-triggered C-C bond cleavage/addition/Kornblum oxidation cascade of oxime esters and styrenes: synthesis of ketonitriles

A photoredox-catalyzed iminyl radical-triggered C-C bond cleavage/addition/Kornblum oxidation cascade of cycloketone oxime esters and styrenes in DMSO is described. This three-component, one-pot procedure features mild conditions, a broad substrate scope, and high functional group tolerance, providi...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018-10, Vol.54 (86), p.12262-12265
Hauptverfasser: He, Bin-Qing, Yu, Xiao-Ye, Wang, Peng-Zi, Chen, Jia-Rong, Xiao, Wen-Jing
Format: Artikel
Sprache:eng
Schlagworte:
Cleavage
Esters
Functional groups
Oxidation
Styrenes
Substrates
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Zusammenfassung:A photoredox-catalyzed iminyl radical-triggered C-C bond cleavage/addition/Kornblum oxidation cascade of cycloketone oxime esters and styrenes in DMSO is described. This three-component, one-pot procedure features mild conditions, a broad substrate scope, and high functional group tolerance, providing an efficient approach to access diversely functionalized ketonitriles. A photoredox-catalyzed iminyl radical-triggered C-C bond cleavage/addition/Kornblum oxidation cascade of cycloketone oxime esters and styrenes in DMSO is described for the first time.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc07072e