Choline ionic liquid enhances the stability of Herceptin® (trastuzumab)

Choline ionic liquid enhances the stability of Herceptin® (trastuzumab)

We investigated the effect of an emerging biocompatible ionic liquid, choline dihydrogen phosphate (CDHP), on the stability of high-concentration formulations of Herceptin® (trastuzumab). Our results show that CDHP significantly suppresses unfolding and aggregation of trastuzumab, demonstrating grea...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018-09, Vol.54 (75), p.1622-1625
Hauptverfasser: Reslan, Mouhamad, Ranganathan, Vijayaraghavan, Macfarlane, Douglas R, Kayser, Veysel
Format: Artikel
Sprache:eng
Schlagworte:
Biocompatibility
Choline
Formulations
Immunotherapy
Ionic liquids
Ions
Monoclonal antibodies
Stability
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Zusammenfassung:We investigated the effect of an emerging biocompatible ionic liquid, choline dihydrogen phosphate (CDHP), on the stability of high-concentration formulations of Herceptin® (trastuzumab). Our results show that CDHP significantly suppresses unfolding and aggregation of trastuzumab, demonstrating great promise as an additive in the development of stable therapeutic antibody formulations. Choline dihydrogen phosphate (CDHP) suppresses trastuzumab unfolding and early-stage aggregation
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc06397d