Biotin-tagged fluorescent sensor to visualize 'mobile' Zn 2+ in cancer cells
A cancer cell-targeting fluorescent sensor has been developed to image mobile Zn2+ by introducing a biotin group. It shows a highly selective response to Zn2+ in vitro, no toxicity in cellulo and images 'mobile' Zn2+ specifically in cancer cells. We believe this probe has the potential to...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2018-08, Vol.54 (69), p.9619-9622 |
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| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A cancer cell-targeting fluorescent sensor has been developed to image mobile Zn2+ by introducing a biotin group. It shows a highly selective response to Zn2+ in vitro, no toxicity in cellulo and images 'mobile' Zn2+ specifically in cancer cells. We believe this probe has the potential to help improve our understanding of the role of Zn2+ in the processes of cancer initiation and development. |
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| ISSN: | 1359-7345 1364-548X |
| DOI: | 10.1039/C8CC05425H |