A chemically encoded timer for dual molecular delivery at tailored ranges and concentrations

Spatiotemporal control of molecular distribution is much in demand in many fields of chemistry. To address this goal, we exploit a low molecular weight branched self-immolative architecture, which acts as a triggerable chemically encoded timer for autonomous sequential release of two chemicals. Using a light-activated model liberating two distinct fluorophores, we generated a tunable spatially contrasted molecular distribution. Spatiotemporally controlled dual delivery: a small molecular timer was designed to release two chemicals at programmed intervals, which could be tuned in a wide range.