Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein-Ru(carbene) adduct

Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein-Ru(carbene) adduct

The first X-ray structures of adducts formed between a Ru II (N-heterocyclic carbene)(η 6 - p -cymene) compound and a protein are reported. Coordination to the protein induced the cleavage of the cymene ligand and EPR spectroscopy demonstrated the oxidation of the Ru centre. The first crystallograph...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018-06, Vol.54 (48), p.612-6123
Hauptverfasser: Sullivan, Matthew P, Nieuwoudt, Michél K, Bowmaker, Graham A, Lam, Nelson Y. S, Truong, Dianna, Goldstone, David C, Hartinger, Christian G
Format: Artikel
Sprache:eng
Schlagworte:
Adducts
Anticancer properties
Ligands
Oxidation
Proteins
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Zusammenfassung:The first X-ray structures of adducts formed between a Ru II (N-heterocyclic carbene)(η 6 - p -cymene) compound and a protein are reported. Coordination to the protein induced the cleavage of the cymene ligand and EPR spectroscopy demonstrated the oxidation of the Ru centre. The first crystallographic study of a Ru(carbene)-protein adduct is complemented by EPR spectroscopy showing Ru oxidation upon binding.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc02433b