A promising dual mode SPECT/CT imaging platform based on 99m Tc-labeled multifunctional dendrimer-entrapped gold nanoparticles

A promising dual mode SPECT/CT imaging platform based on 99m Tc-labeled multifunctional dendrimer-entrapped gold nanoparticles

Multifunctional Tc-labeled dendrimer-entrapped gold nanoparticles ( Tc-Au DENPs) were designed and synthesized. Our results show that the type of surface groups (acetyl or hydroxyl) significantly impact the biodistribution profile of the Tc-Au DENPs, thereby allowing for preferential SPECT/CT imagin...

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Veröffentlicht in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2017-06, Vol.5 (21), p.3810-3815
Hauptverfasser: Wen, Shihui, Zhao, Lingzhou, Zhao, Qinghua, Li, Du, Liu, Changcun, Yu, Zhibo, Shen, Mingwu, Majoral, Jean-Pierre, Mignani, Serge, Zhao, Jinhua, Shi, Xiangyang
Format: Artikel
Sprache:eng
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Zusammenfassung:Multifunctional Tc-labeled dendrimer-entrapped gold nanoparticles ( Tc-Au DENPs) were designed and synthesized. Our results show that the type of surface groups (acetyl or hydroxyl) significantly impact the biodistribution profile of the Tc-Au DENPs, thereby allowing for preferential SPECT/CT imaging of different organs.
ISSN:2050-750X
2050-7518
DOI:10.1039/C7TB00543A